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EC Number
Activating Compound
Commentary
Reference
2.7.4.14
dithiothreitol
1 mM, activates
645149
2.7.4.14
2-mercaptoethanol
activates
645143
2.7.4.14
dithiothreitol
activates
645143
,
645149
2.7.4.14
glutathione
activates
645143
2.7.4.14
L-Cys
activates
645143
2.7.4.14
reduced DL-alpha-lipoic acid
activates
645143
2.7.4.14
thioredoxin
activates
645142
2.7.4.14
thioredoxin
activity is strictly dependent upon sulfhydryl reducing agents. Reduced thioredoxin is by far the most effective
645139
,
645143
2.7.4.14
2-mercaptoethanol
at 5 mM: reduction in molecular weight from approximately 53000 Da to 17000 Da. This low molecular weight form is partially active in the presence of 2-mercaptoethanol. In absence of 2-mercaptoethanol the low molecular weight form is inactive. At 50 mM: full reactivation of the CMP(ATP) kinase activity followed by dCMP(ATP) and CMP(dCTP)
645142
2.7.4.14
doxorubicin
binding of doxorubicin to the enzyme (CMPK1) activates the phosphorylation of CMP, dCMP, and UMP. Doxorubicin might bind to the nonactive site of CMPK1 and regulate its activity with magnesium
762474
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