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EC Number
Activating Compound
Commentary
Reference
3-amino-1-methyl-5H-pyrido[4,3-b]indole
i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
ATP
5-10 mM, 20-30% stimulation
Bmh1p
a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview
DNA
absolute requirement
DNA
enzyme has an N-terminal binding domain
DNA
required
DNA
slightly increases activity
DNA
the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1
FAS
exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS
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