EC Number   |
Activating Compound |
Reference |
|---|
   1.14.14.94 | all-trans retinoic acid |
significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured HL-60 cells |
703413 |
| 1.14.14.94 | all-trans-retinoic acid |
after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f39 are up-regulated. No changes in transcript abundance for the Cyp4f16, 4f17, and 4f18 genes |
701913 |
| 1.14.14.94 | Benzene |
induces CYP4F3 in human blood cells both in vivo and in vitro |
703413 |
| 1.14.14.94 | lipopolysaccharide |
upregulates expression and activity of LTB4OH in ex-smokers in a dose-dependent manner, but not in smokers. In vitro smoke exposure of ex-smokers' bronchoalveolar lavage cells abrogates the lipopolysaccharide-induced up-regulation of LTB4OH mRNA expression, thus tobacco smoke alters bronchoalveolar lavage cell LTB4OH mRNA expression in response to lipopolysaccharide exposure |
703013 |
| 1.14.14.94 | more |
CYP4F18 expression is induced in bone marrow-derived dendritic cells by bacterial lipopolysaccharide, a ligand for TLR4, and by poly(I-C), a ligand for TLR3 |
674761 |
| 1.14.14.94 | more |
hepatic enzyme is not induced by phenobarbital or 3-methylcholanthrene |
390063 |
| 1.14.14.94 | phenol |
significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured and differentiated HL-60 cells, in the proerythroid cell line K-562, and ex vivo in human neutrophils |
703413 |
