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Results 1 - 10 of 27 > >>
EC Number
Activating Compound
Commentary
Reference
(6R,S)-Methyl-tetrahydropterin
activation in the absence of biopterin, not as effective as tetrahydrobiopterin
A-23187
low levels of A-23187 stimulate nNOS activity
Acetylsalicylic acid
maximal activation at 0.004 mM
Ca2+/calmodulin
activate the electron transfer
Ca2+/calmodulin
calmodulin activates electron transfer from NADPH through three reductase domains to the oxygenase domain, controls constitutive isoforms through regulation of electron transfer between NADPH and heme
Ca2+/calmodulin
calmodulin activates electron transfer from NADPH through three reductase domains to the oxygenase domain, controls constitutive isoforms through regulation of electrontransfer between NADPH and heme
Calmodulin
-
Calmodulin
activates O2 consumption of eNOS
Calmodulin
activates the neuronal NOS by binding and inhibiting the suppression through the C-terminal tail of the enzyme, overview
Calmodulin
Ca2+-calmodulin binds between the reductase and oxygenase domains to activate nitric-oxide synthesis. The enzyme adopts an ensemble of open and closed conformational states and that Ca2+-calmodulin binding induces a dramatic rearrangement of the reductase domain. Calmodulin-specific activation triggers release and rotation of the FMN subdomain to expose the flavin for electron transfer to the heme
Results 1 - 10 of 27 > >>