EC Number |
Activating Compound |
Reference |
---|
1.11.2.2 | ascorbic acid |
200% activation at 0.002 mM and pH 5.2 |
439757 |
1.11.2.2 | D-penicillamine |
addition of D-penicillamine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (17.2% increase at 5 mM) |
713543 |
1.11.2.2 | glutathione |
addition of glutathione significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (24% increase at 5 mM) |
713543 |
1.11.2.2 | L-cysteine |
addition of L-cysteine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (45.4% increase at 5 mM) |
713543 |
1.11.2.2 | N-acetyl-L-cysteine |
addition of N-acetyl-L-cysteine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (16.3% increase at 5 mM) |
713543 |
1.11.2.2 | serotonin |
at low micromolar concentrations (below 0.02 mM), serotonin enhances hypochlorite production by both purified myeloperoxidase and neutrophils |
711135 |
1.11.2.2 | indicaxanthin |
at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO |
711064 |
1.11.2.2 | ascorbic acid |
converts inactive myeloperoxidase compound II into active myeloperoxidase |
711274 |
1.11.2.2 | ferrocyanide |
converts inactive myeloperoxidase compound II into active myeloperoxidase |
711274 |
1.11.2.2 | 5-aminosalicylic acid |
converts inactive myeloperoxidase compound II rapidly into active myeloperoxidase |
711274 |