EC Number   |
Activating Compound |
Reference |
|---|
   3.4.21.47 | mannan-binding lectin |
mannan-binding lectin (MBL) promotes activation of complement component C3 through the combined action of MBL-associated serine proteases MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, experimental conditions described |
680169 |
| 3.4.21.47 | more |
complement activation via the lectin pathway on zymosan particles is at least 4times more efficient than via the classical pathway on sheep erythrocytes coated with antibody. Every C4b deposited via the lectin pathway is capable of forming a convertase in contrast to only one of four C4b molecules deposited via the classical pathway. Rate of formation of lectin pathway C3/C5 convertases depends on the activation of C4 and C2 by MASP-2 |
698871 |
| 3.4.21.47 | more |
high surface density of complement component C3b is critical for the enzyme activity |
753082 |
| 3.4.21.47 | more |
proteolytic conversion of C3 to C3b in hemocyanin-depleted plasma is not induced by zymosan, peptidoglycan, or laminarin |
699342 |
| 3.4.21.47 | phorbol myristate acetate |
treatment of whole blood leads to stimulation of neutrophils resulting in activation of the alternative complement pathway and release of C5 fragments, which further amplify proinflammatory responses |
717421 |
| 3.4.21.47 | properdin |
facilitates AP complement activation by stabilizing the C3 convertase C3bBb, essential for AP complement activation induced by bacterial lipopolysacharide (LPS) and lipooligosacharide (LOS) and other AP complement activators |
683294 |
| 3.4.21.47 | properdin |
positive regulator of the alternative pathway, no direct interaction with the decay-accelerating factor DAF determined |
683734 |
| 3.4.21.47 | properdin |
properdin (Factor P) binding to the erythrocyte membranes is necessary for C3b to attach and initiate alternative pathway activation |
732572 |
| 3.4.21.47 | properdin |
surface plasmon resonance assays, properdin promotes the association of C3b with factor B and provides a focal point for the assembly of enzyme on a surface. Properdin can use its unoccupied C3b-binding sites as receptors and form a lattice of properdin-C3b, -C3bB and C3bBb complexes leading to in situ assembly of enzyme |
669478 |
| 3.4.21.47 | tumor necrosis factor-alpha |
treatment of whole blood leads to stimulation of neutrophils resulting in activation of the alternative complement pathway and release of C5 fragments, which further amplify proinflammatory responses |
717421 |
