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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.27thrombin activates FXI. FXI activation by thrombin is enhanced by charged substances, such as dextran sulfate or heparin. Thrombin binds to the A1 domain of FXI, with residues Glu66, Lys83, and Gln84 forming part of the binding site. The dimer is required for optimal FXI activation by thrombin 707856
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.27thrombin FXI activation proceeds through an intermediate with only one activated submit 709721
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.27thrombin the enzyme can be activated, albeit slowly, by thrombin 731773
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.27thrombin thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor 709722
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