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EC Number
Activating Compound
Commentary
Reference
3.4.21.27
Dextran sulfate
33nM
667620
3.4.21.27
Factor XII
-
718045
3.4.21.27
Factor XII
FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade
709722
3.4.21.27
factor XIIa
-
717420
,
718042
,
731773
,
732936
,
753068
3.4.21.27
factor XIIa
using a 10:1 molar ratio of FXI to FXIIa at 37°C
717844
3.4.21.27
FXIa
-
669420
3.4.21.27
FXIIa
-
667620
,
669420
3.4.21.27
kininogen
-
36529
3.4.21.27
meizothrombin
cleaves FXI at the Arg369-Ile370 bond
707856
3.4.21.27
more
activation of factor XI by thrombin and autoactivation to factor XIa
36539
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