EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.10 | more |
herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells |
660649 |
| 2.7.11.10 | more |
hypoxia activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta |
676834 |
| 2.7.11.10 | more |
IKK induction by cytokines, transcriptional activation by CREB-binding protein, i.e. CBP, after N-terminally binding to NEMO, which competes with IKKalpha and p65 |
662249 |
| 2.7.11.10 | more |
IKK is induced by TNFalpha |
661333, 662156 |
| 2.7.11.10 | more |
IKKbeta is activated by phosphorylation at Ser171 and Ser181 of the activation loop |
673483 |
| 2.7.11.10 | more |
IKKgamma phosphorylation by IKKbeta is induced by the cytokine TNF-R1, IKKbeta is recruited to the cytoplasmic tail of TNF-R1 by adaptor proteins, such as RIP |
662437 |
| 2.7.11.10 | more |
IKKgamma phosphorylation by IKKbeta is induced by the cytokine TNFalpha and the viral oncoprotein Tax |
662136 |
| 2.7.11.10 | more |
infection and genome insertion of human cytomegalovirus induces expression of the catalytic subunit IKK2 in the host cell which is required for viral induction of NF-kappaB activation and involved in viral replication and lytic cycle |
662736 |
| 2.7.11.10 | more |
lipopolysaccharides from Escherichia coli induce enzyme activity versus RelA/p65 and NFkappaB activation in vivo, induction is not inhibited by LY294002, overview |
662570 |
| 2.7.11.10 | more |
lipopolysaccharides stimulate cytokine-mediated IKK activity being positively feedback regulated |
663395 |
