EC Number   |
Activating Compound |
Reference |
|---|
   1.14.13.39 | Calmodulin |
required for catalysis |
687291 |
| 1.14.13.39 | Calmodulin |
substrate 2,6-dichlorophenolindophenol, about 10fold increase in activity in presence of calmodulin |
657741 |
| 1.14.13.39 | dithiothreitol |
- |
440234, 440235, 440236, 440238, 440240 |
| 1.14.13.39 | dithiothreitol |
requirement |
440207 |
| 1.14.13.39 | heat shock protein 90 |
heat shock protein 90 enhances the affinity of wild-type enzyme to NADPH, L-arginine, and calmodulin but not to Ca2+ and BH4 |
746226 |
| 1.14.13.39 | interferon gamma |
activates |
440201, 440238 |
| 1.14.13.39 | L-arginine |
L-arginine strongly stimulates oxygen consumption of eNOS and inhibits that of nNOS, nonhydrolyzable L-arginine analogues are not stimulatory |
687615 |
| 1.14.13.39 | lipopolysaccharide |
from Escherichia coli, activates |
440238 |
| 1.14.13.39 | more |
design and synthesis of a series of two-photon absorbing and photoactivatable NADPH analogues (NT 1 and NT2). These compounds bear one or two carboxymethyl group(s) on the 2'- or/and 3'-position(s) of the ribose in the adenosine moiety, instead of a 2'-phosphate group, and differ by the nature of the electron donor in their photoactivatable chromophore (replacing the nicotinamide moiety). Ability of NTs to photoinduce eNOS-dependent NO production in endothelial cells. Two compounds, those bearing a single carboxymethyl group on the 3'-position of the ribose, colocalize with the Golgi apparatus (the main intracellular location of eNOS) and display high intracellular two-photon brightness. Furthermore, a eNOS-dependent photooxidation is observed for these two compounds only, which is accompanied by a substantial intracellular NO production accounting for specific photocytotoxic effects. NT photoactivation efficiently triggers electron flow at the eNOS level and increases the basal production of NO by endothelial cells, structure-activity relationship of NTs in the cell context, overview |
764203 |
| 1.14.13.39 | more |
fibroblast growth factor-2 teratment up-regulates the enzyme in tectume, but down-regultes it in the optic nerve, overview |
672844 |
