EC Number   |
Activating Compound  |
Reference |
|---|
    2.4.2.30 | GDP |
increases activity in absence of Mg2+ |
637994 |
| 2.4.2.30 | GTP |
increases activity in absence of Mg2+ |
637994 |
| 2.4.2.30 | GTP(gammaS) |
increases activity in absence of Mg2+ |
637994 |
| 2.4.2.30 | harmaline hydrochloride |
activates more strongly in absence of Mg2+ than in presence of Mg2+ |
637997 |
| 2.4.2.30 | Mg2+ |
5 mM, 6.3fold activation |
725034 |
| 2.4.2.30 | more |
DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview |
672969 |
| 2.4.2.30 | more |
in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity |
662087 |
| 2.4.2.30 | more |
PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death |
671255 |
| 2.4.2.30 | more |
stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme |
671265 |
| 2.4.2.30 | oligodeoxyribonucleotides |
slightly enhance enzyme activity with the maximal increase of 50% as compared to the control |
725600 |
