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<< < Results 11 - 20 of 25 > >>
EC Number Activating Compound Commentary Reference
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview 672969
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30DNA enzyme has an N-terminal binding domain 638000
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30FAS exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS 662089
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.303-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM 675627
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity 662087
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30GDP increases activity in absence of Mg2+ 637994
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30GTP increases activity in absence of Mg2+ 637994
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30GTP(gammaS) increases activity in absence of Mg2+ 637994
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death 671255
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30DNA required 637998
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