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EC Number
Activating Compound
increases activity in absence of Mg2+
increases activity in absence of Mg2+
increases activity in absence of Mg2+
harmaline hydrochloride
activates more strongly in absence of Mg2+ than in presence of Mg2+
5 mM, 6.3fold activation
DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview
in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity
PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death
stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme
slightly enhance enzyme activity with the maximal increase of 50% as compared to the control
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