5.5.1.13 A710C no change in reaction product profile compared to wild-type 714971 5.5.1.13 A710C site-directed mutagenesis, the mutant shows unaltered activity and reaction product profile compared to the wild-type Jungermannia subulata JsCPS/KS 714971 5.5.1.13 A710F mutant converts geranylgeranyl diphosphate to ent-kaurene as the sole product 714971 5.5.1.13 A710F site-directed mutagenesis, the mutant protein shows the same enzymic activity as wild-type Jungermannia subulata JsCPS/KS 714971 5.5.1.13 A710G no change in reaction product profile compared to wild-type 714971 5.5.1.13 A710G site-directed mutagenesis, the mutant shows unaltered activity and reaction product profile compared to the wild-type Jungermannia subulata JsCPS/KS 714971 5.5.1.13 A710L the substitution changes the ratio of ent-kaurene and 16alpha-hydroxy-entkaurane produced. The production of ent-kaurene is increased to the same level as that of 16alpha-hydroxyent-kaurane 714971 5.5.1.13 A710M mutant converts geranylgeranyl diphosphate to ent-kaurene as the sole product 714971 5.5.1.13 A710M site-directed mutagenesis, the mutant protein shows the same enzymic activity as wild-type Jungermannia subulata JsCPS/KS 714971 5.5.1.13 A710N no change in reaction product profile compared to wild-type 714971