3.4.22.B79	A662T	temperature-sensitive in vivo and in vitro	679819	
3.4.22.B79	C478A	complete loss of activity	755486	
3.4.22.B79	C478A	inactive	679819	
3.4.22.B79	C478A	mutation in active site, loss of activity	-, 753844	
3.4.22.B79	C478A	residue Cys478 in the active site of CHIKV nsP2 is indispensable for polyprotein P1234 processing. Mutation completely abolishes RNA replication trans-replication systems and abolishes the rescue of infectious virus from CHIKV RNA transcripts	-, 755448	
3.4.22.B79	C478A	significantly less activity than wild type for the 2-(N-methylamino)benzoyl-AGAGIIETk(Dnp)substrate	-, 755412	
3.4.22.B79	C481G	mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal	29849	
3.4.22.B79	C481R	mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal	29849	
3.4.22.B79	C481S	mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal	29849	
3.4.22.B79	C525R	mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal	29849