2.3.2.32	A253R	inactive	745760	
2.3.2.32	A253R/D259A	inactive	745760	
2.3.2.32	D226A	inactive	745760	
2.3.2.32	D226A/A253R	inactive	745760	
2.3.2.32	D226A/A253R/D259A	inactive	745760	
2.3.2.32	D226A/D259A	inactive	745760	
2.3.2.32	D259A	inactive	745760	
2.3.2.32	I44A	the mutation reduces cullin NEDD8ylation activity	745761