1.14.16.7 C187F hydroxylation rate is reduced to less than 4% compared to the rate of wild-type enzyme 724321 1.14.16.7 C187F/T202G hydroxylation rate is comparable to that of wild-type enzyme. Less than 8% of m-Tyr compared to p-Tyr is formed 724321 1.14.16.7 T202G hydroxylation rate is comparable to that of wild-type enzyme. The ratio of product p-Tyr to m-Tyr is changed to 2:1 for the T202G mutant, which represents a 60-fold increase in the preference for p-Tyr over m-Tyr formation 724321