4.6.1.12	Arg142Met, Glu144Leu	dual mutation with little influence on both the overall structure and the detail in the active site	663548	
4.6.1.12	additional information	Arabidopsis enzyme null mutants are albino lethal. Chloroplasts of mutants are filled with vesicles instead of thylakoids. Expression of enzyme in Escherichia coli can rescue the lethal phenotype of an Escherichia coli ispF mutant	682464