3.4.24.84	E298A	ability to complement the mating-defective phenotype of ste24-1 is lost	638973	
3.4.24.84	E298D	ability to complement the mating-defective phenotype of ste24-1 is lost	638973	
3.4.24.84	H297A	ability to complement the mating-defective phenotype of ste24-1 is lost	638973	
3.4.24.84	L647R	prelaminaAct mutant, cannot be cleaved by Zmpste24	667497	
3.4.24.84	additional information	Zmste24-deficient mice, Zmpste24 deficiency elicits a stress signaling pathway that is evidenced by a marked upregulation of p53 target genes, accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level	670378	
3.4.24.84	additional information	identification of compound heterozygous frameshifting mutations in exon 1, c.50delA, and exon 5, c.584_585delAT of the ZMPSTE24 gene in two brothers affected with restrictive dermopathy, who died in the neonatal period. Both deletions are frameshifting and are predicted to cause the appearance of premature termination codons	710803	
3.4.24.84	L362F	the mutation is associated with restrictive dermopathy	719313	
3.4.24.84	additional information	neonates with restrictive dermopathy have homozygous or compound heterozygous null mutations in the ZMPSTE24 gene	719313	
3.4.24.84	W302X	the mutation is associated with restrictive dermopathy	719313	
3.4.24.84	H335A	0.4% of wild-type activity	735044