3.4.24.84 E298A ability to complement the mating-defective phenotype of ste24-1 is lost 638973 3.4.24.84 E298D ability to complement the mating-defective phenotype of ste24-1 is lost 638973 3.4.24.84 H297A ability to complement the mating-defective phenotype of ste24-1 is lost 638973 3.4.24.84 H335A 0.4% of wild-type activity 735044 3.4.24.84 H335A the mutant shows 1.5% of wild type activity 753395 3.4.24.84 H339A the mutant shows 1.9% of wild type activity 753395 3.4.24.84 L362F 1.3% of wild-type activity 735044 3.4.24.84 L362F the mutation is associated with restrictive dermopathy 719313 3.4.24.84 L425P the mutation is associated with mandibuloacral dysplasia type B and reduced prelamin A cleavage ability (41.9% of wild type activity) 753395 3.4.24.84 L438F 1.0% of wild-type activity 735044