3.4.21.B26 additional information knockout of the enzyme by siRNA 732515 3.4.21.B26 additional information Pcsk5delta4-deficient allele missing exon 4 that encodes the catalytic Asp173, delta4/delta4 genotype is embryonic lethal, heterozygote mice are healthy and fertile 675967 3.4.21.B26 additional information stable knockout of the enzyme in HEC-1-A cells by specific siRNA 731899