3.4.21.41	C309W	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	C338R	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	C358F	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	C371W	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	D290G	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	G297D	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	I306-C309del	the deletion mutations are associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	L300P	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432	
3.4.21.41	additional information	by the point mutation of C1r - Arg-Phe - of the natural cleavage site Arg-Ile - the zymogen is stabilized, while the biological activity is not affected	81401	
3.4.21.41	R301P	the mutation is associated with periodontal Ehlers-Danlos syndrome	752432