3.4.21.27	C147S	inactive	754516	
3.4.21.27	C321S	the mutant shows wild type activity	754516	
3.4.21.27	C362S/C482S	site-directed mutagenesis	683682	
3.4.21.27	C362S/C482S	site-directed mutagenesis, the mutant shows increased platelet binding compared to the wild-type enzyme	683160	
3.4.21.27	C398Y	exhibits a dominant negative effect when coexpressed with wild-type FXI and is associated with FXI deficiency that may be inherited in a dominant manner	707856	
3.4.21.27	C482S	the mutant shows 1.45fold enhanced activity as compared with the wild type enzyme	754516	
3.4.21.27	C500S	inactive	731076	
3.4.21.27	E98A	the mutant has normal Km and kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis, and is inhibited by protease nexin 2 with normal value of Ki	717844	
3.4.21.27	E98D	the mutant has normal Km and decreased kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis	717844	
3.4.21.27	E98V	the mutant has increased Km and decreased kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis	717844