3.1.3.56	T16A	100% of activity	646400	
3.1.3.56	F392A	50% of activity	646400	
3.1.3.56	additional information	construction of transgenic Arabidopsis thaliana plants expressing the human enzyme, the transgenic plants show no altered growth and life cycle phenotype although the basal level of inositol 1,4,5-trisphosphate is reduced by 90% compared to wild-type plants, but the plants are insensitive to gravitropic stimulation and show no increased InsP3 levels in inflorescence stem under gravistimulation in contrast to wild-type plants, bending responses, overview	666645	
3.1.3.56	C409S	decreased activity	646397	
3.1.3.56	C939S	eliminates isoprenylation of enzyme which reduces activity towards phosphatidylinositol 4,5-bisphosphate	646393	
3.1.3.56	DELTA725-1001	enzyme exclusively cytoplasmic	646399	
3.1.3.56	DELTA1-433	enzyme mainly in cytoplasm	646399	
3.1.3.56	R350A	increased Km	646396	
3.1.3.56	R343A	increased Km and dramatic loss of activity	646396	
3.1.3.56	D232A	no activity	646400