2.6.1.5 N17S increase in Km-values, substantial decrease in kcat-values 660454 2.6.1.5 R20A increase in Km-values, substantial decrease in kcat-values 660454 2.6.1.5 C151Y missense mutation leading to defective folding and likely alteration of the enzymatic activity 676025 2.6.1.5 L273P missense mutation leading to defective folding and likely alteration of the enzymatic activity 676025 2.6.1.5 R41A mutant is inactive when tested with (S)-beta-phenylalanine as amino donor and 2-oxoglutarate as amino acceptor 721359 2.6.1.5 R417Q no enzymic activity 660454 2.6.1.5 R57A no enzymic activity 660454 2.6.1.5 R57Q no enzymic activity 660454 2.6.1.5 I249A reduced catalytic activity 673540 2.6.1.5 N54S reduced enzymic activity 660454