1.7.1.13 C190A complete loss of activity 724767 1.7.1.13 D197N complete loss of activity 724767 1.7.1.13 E230Q about 4% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one 724767 1.7.1.13 F228W about 8% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one 724767 1.7.1.13 H229A about 15% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one 724767 1.7.1.13 Q89A poor activity 724767 1.7.1.13 Q89L poor activity 724767 1.7.1.13 S90A about 10% of wild-type activity for natural substrate 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one 724767 1.7.1.13 C99A mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible -, 742061 1.7.1.13 C99S mutant does not compromise enzyme activity. Contrary to wild-type, peroxide-induced inactivation is irreversible -, 742061