4.1.3.16 C257G natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 DeltaE315 natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 G287V natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 G287V the mutation is associated with primary hyperoxaluria type 3 748294 4.1.3.16 K196A complete loss of activity 723542 4.1.3.16 N78A 20% of wild-type activity 723542 4.1.3.16 N78Q 4% of wild-type activity 723542 4.1.3.16 N78T 45% of wild-type activity 723542 4.1.3.16 P190L natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 P190L the mutation is associated with primary hyperoxaluria type 3 748294 4.1.3.16 R255X a truncation of 71 residues from the C-terminus associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 R303C natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 R70P natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 R97C natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 S198A 9% of wild-type activity 723542 4.1.3.16 S198T 18% of wild-type activity 723542 4.1.3.16 S77A 5% of wild-type activity 723542 4.1.3.16 S77T 2% of wild-type activity 723542 4.1.3.16 S77V 2% of wild-type activity 723542 4.1.3.16 T280I natural mutation associated with Primary Hyperoxaluria type 3. Mutant is quite unstable, has a tendency to aggregate, and retains no measurable activity 721727 4.1.3.16 Y140F 122% of wild-type activity 723542 4.1.3.16 Y168F complete loss of activity 723542 4.1.3.16 Y39X/R70X naturally occuring mutations in a patient with type 3 atypical primary hyperoxaluria 728378