3.4.24.84	W340R	the mutant shows 41.7% of wild type activity	753395	
3.4.24.84	W340R/L362F	the mutations are associated with mandibuloacral dysplasia type B and reduced prelamin A cleavage ability	753395	
3.4.24.84	Y399C	the mutation is associated with mandibuloacral dysplasia type B and reduced prelamin A cleavage ability(25.8% of wild type activity)	753395	
3.4.24.84	L94P	the mutation severely impairs enzyme activity	755334