3.4.17.23 H378R non-synonymous single nucleotide polymorphism 765112 3.4.17.23 H378R the variant in the binding region increases disease susceptibility towards SARS-CoV-2 762786 3.4.17.23 H505A 1.5% of wild-type activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl as substrate 668550 3.4.17.23 H505L no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl 668550 3.4.17.23 I21V the variant in the binding region increases disease susceptibility towards SARS-CoV-2 762786 3.4.17.23 I468V deleterious missense variant 762786 3.4.17.23 K26R missense variant, mutation affect protein structure and stability 762786 3.4.17.23 K26R the variant in the binding region increases disease susceptibility towards SARS-CoV-2 762786 3.4.17.23 K31R variant exhibits lower binding to SARS-CoV-2 S protein 762786 3.4.17.23 K341R deleterious missense variant 762786