3.1.6.14 C80A inactive 704598 3.1.6.14 D186A 53% relative activity after 0.5 h and 92% relative activity after 5 h compared to the wild type enzyme 704598 3.1.6.14 D374A inactive 704598 3.1.6.14 additional information mutation of glutamine 390 to stop-codon causes Mucopolysaccharidosis type IIID 677855 3.1.6.14 additional information silencing the expression of Sulf-1 by RNA interference restores the responses induced by FGF-1, which indicates that TNF-alpha-mediated induction of the sulfatase results in alterations of HS biological properties 761256 3.1.6.14 R102X nonsense mutation 135594