2.7.1.86 G183R mutant with partially retained NADH kinase activity 2.7.1.86 H231D the mutant exhibits no activity towards NAD+ and low activity for NADH 2.7.1.86 R293H the mutation reduces the ratio of NADH kinase activity to NAD kinase activity from 8.6 to 2.1 2.7.1.86 R293H/H231D inactive