2.3.1.12	G610C	500fold reduced enzymatic activity	486228	
2.3.1.12	H602C	inactive	736448	
2.3.1.12	I176A	mutation in the inner lipoyl-bearing domain (L2), pyruvate dehydrogenase kinase 2 binding: not measurable	672273	
2.3.1.12	I229A	ability to be post-translationally lipoylated remains	486229	
2.3.1.12	I229A/F231A	ability to be post-translationally lipoylated remains, far-UV CD spectrum differs from wild-type enzyme	486229	
2.3.1.12	K136A	site-directed mutagenesis, thermodynamics and kinetics in comparison to the wild-type enzyme	661632	
2.3.1.12	K153A	site-directed mutagenesis, thermodynamics and kinetics in comparison to the wild-type enzyme	661632	
2.3.1.12	K173A	mutation in the inner lipoyl-bearing domain (L2), pyruvate dehydrogenase kinase 2 binding: not measurable	672273	
2.3.1.12	K191E	the mutant shows 50% activity compared to the wild type enzyme	725521	
2.3.1.12	K191R	the mutant shows 79% activity compared to the wild type enzyme	725521