2.1.1.208 E234A 20% of wild-type activity 709512 2.1.1.208 E234Q 70% of wild-type activity 709512 2.1.1.208 N139A less than 5% of wild-type activity 709512 2.1.1.208 N262A less than 5% of wild-type activity 709512 2.1.1.208 N262Q 60% of wild-type activity 709512 2.1.1.208 R145A less than 5% of wild-type activity 709512 2.1.1.208 T135V 110% of wild-type activity 709512