1.8.4.9 additional information construction of transgenic Arabidopsis thaliana plants expressing the active enzyme from Pseudomonas aeruginosa in the chloroplasts, the plants show reduced fresh and dry weight, delayed germination, smaller leaves, slightly reduced fertility, and increased enzyme activity and sulfate reduction accumulating of sulfite, thiosulfate, cysteine, gamma-glutamylcysteine, and glutathione, feeding of O-acetylserine leads to increased accumulation of sulfite and thiosulfate in the transgenic plants, phenotype alterations, overview 1.8.4.9 additional information gene APR1, the holoenzyme APR1p as well as the C-domain alone can complement the cysteine auxotrophy of an Escherichia coli cysH mutant strain, substituting for glutaredoxin, if the mutant is capable of producing glutathione, cysH encodes the 5'-phosphoadenylylsulfate reductase in Escherichia coli 1.8.4.9 additional information construction of APR-B knockout plants, the mutant plants are able to grow on sulfate as a sole sulfur source, and the content of low molecular weight thiols is not different from wild-type plants. However, when treated with low concentrations of cadmium, the APR-B knockout plants are more sensitive than wild-type plants, phenotype, overview 1.8.4.9 additional information regulation of APR by NaCl is not affected in mutant plants deficient in the abscisic acid synthesis, but APR is induced in mutant plants deficient in jasmonate, salicylate, ethylene, cytokinin, and auxin signaling, while the enzyme activity remians unaltered, the induction by salt is abolished in mutant plants deficient in gibberellic acid signaling, overview 1.8.4.9 additional information generation of the APR2 T-DNA insertion mutant (apr2-1), knockout of isozyme APR2 reduces the overall APR activity by 80%, phenotype, overview