1.3.98.1 N67A drastically reduced activiy 656148 1.3.98.1 P131A decrease in activtiy against fumarate 656148 1.3.98.1 P56A drastically reduced activiy 656148 1.3.98.1 Q7L single nucleotide polymorphism due to missense polymorphism 19C>A, leading to amino acid substitution in the cationic N-terminal region of the polypeptide 700606 1.3.98.1 R265A 2fold increase in KM-value of CoQD, 15% increase in KM-value of L-dihydroorotate 656285 1.3.98.1 R50E little changes in activity 656148 1.3.98.1 R57A increase in activity 656148 1.3.98.1 S129A decrease in activtiy against fumarate 656148 1.3.98.1 S175A - 390913 1.3.98.1 S175A low activity with dihydroorotate, increasing activity above pH 8.0 with dihydrooxonate 390913