1.14.11.27	H188A	inactive	764639	
1.14.11.27	H211A	inactive mutant	700374	
1.14.11.27	H212A	inactive mutant	-, 726260	
1.14.11.27	H212A	mutation completely abolishes the enzymatic activity	662947	
1.14.11.27	H305A	more than 90% loss of activity	688966	
1.14.11.27	H305A	mutation completely abolishes the enzymatic activity	662947	
1.14.11.27	H319A	a catalytically inactive mutant	724815	
1.14.11.27	additional information	enzyme engineering and swapping of the C-terminus region containing the distal Tudor domain between isozymes KDM4C and KDM4A. Chimera5, which encodes the first 934 amino acids of KDM4C fused with the last 129 amino acid containing the distal Tudor domain of KDM4A, is excluded from mitotic chromatin. On the other hand, chimera6 that encodes the first 954 amino acids of KDM4A fused to 101 amino acids of KDM4C, which includes its distal Tudor domain, remains excluded from chromatin. The C-terminus of KDM4C containing the distal Tudor domain is essential but not sufficient for its mitotic chromatin localization	745919	
1.14.11.27	additional information	enzyme engineering and swapping of the C-terminus region containing the distal Tudor domain between isozymes KDM4C and KDM4A. Chimera5, which encodes the first 934 amino acids of KDM4C fused with the last 129 amino acid containing the distal Tudor domain of KDM4A, is excluded from mitotic chromatin. On the other hand, chimera6 that encodes the first 954 amino acids of KDM4A fused to 101 amino acids of KDM4C, which includes its distal Tudor domain, remains excluded from chromatin. The C-terminus of KDM4C containing the distal Tudor domain is essential but not sufficient for its mitotic chromatin localization. EGFP-KDM4CRDTF/DNLY mutant is excluded from mitotic chromatin. For isozyme knockout, U2OS cells are transfected with KDM4B-C siRNA sequences	745919	
1.14.11.27	additional information	expression of histone demthylase Ndy1 in mouse embryo fibroblast results in immortalization in absence of replicative senescence via a JmjC domain-dependent process that targets the Rb and p53 pathways. Knockdown of endogenous Ndy1 or expression of JmjC domain mutants of Ndy1 promote senescence, suggesting that Ndy1 is a physiological inhibitor of senescence in dividing cells and that inhibition of senescence depends on histone H3 demethylation	689797	
1.14.11.27	additional information	generation of a jhd1DELTA deletion mutant, phenotype overview	744589	
1.14.11.27	additional information	generation of Jmjd5-deficient mice	724815	
1.14.11.27	additional information	histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites	698354	
1.14.11.27	additional information	Jhdm1a knockdown or scramble adenoviruses are transduced into the liver of wild-type male C57BL/6J mice	-, 726260	
1.14.11.27	additional information	Kdm2b/Jhmd1b is required for Hoxa9/Meis1-induced leukemic transformation in vitro	724651	
1.14.11.27	additional information	Ndy1 knockdown by siRNA in fibroblasts. Significant reduction in K36-dimethylated histone H3 associated with the promoters of Nqo1 and Prdx4 genes in cells engineered to overexpress Ndy1 but not its CXXC deletion mutant. Trimethylation of histone H3 at K4 is also reduced in the promoter regions of both genes, though in a spatially restricted manner that spared the region near the transcription start site. But the effect of Ndy1 on histone H3K4 trimethylation is weak	754726	
1.14.11.27	additional information	overexpression results in moderate decrease in dimethyl-histone 3 L-lysine 36 and a slight decrease in trimethyl-histone 3 L-lysine 36 along with unaltered methyl-histone 3 L-lysine 36 levels. Deletion of the N-terminal PHD domain leads to about 50% decrease in activity. Deletion of C-terminal 125, 193, or 244 amino acids results in more than 90% loss of activity	688966	
1.14.11.27	additional information	shRNA knockdown of Jhdm1a in Hep-G2 cells elevating gluconeogenic gene expression	726260	
1.14.11.27	R919D	site-directed mutagenesis, the mutant is not associated with mitotic chromatin in contrast to the wild-type enzyme	745919	
1.14.11.27	S198M	site-directed mutagenesis, a KDM4C demethylase dead mutant	745919	
1.14.11.27	T302A	more than 90% loss of activity	688966	
1.14.11.27	Y315A	more than 90% loss of activity	688966