3.1.4.59	D130A/H131A	mutant fails to hydrolyze c-di-AMP	-, 751993	
3.1.4.59	D134a/H135A/H136A	mutation in DHH domain, complete loss of catalytic activity	-, 750844	
3.1.4.59	D420A	mutant exhibits residual activity against c-di-AMP, c-di-GMP, bis-p-nitrophenol phosphate, and thymidine monophosphate p-nitrophenol ester	-, 751027	
3.1.4.59	D420A/D499A	mutation totally abolishes the catalytic activity	-, 751027	
3.1.4.59	G266D	natural mutation identified in a strain displaying tolerance to inhibitors of peptidoglycan biosynthesis	-, 749591	
3.1.4.59	G313A/G314A/G315A/H316A	mutation in DHHA1 domain, mutasnt displays residual activity	-, 750844	
3.1.4.59	T260K	natural mutation identified in a strain displaying tolerance to inhibitors of peptidoglycan biosynthesis	-, 749591