3.1.3.56	F392A	50% of activity	646400	
3.1.3.56	H184A	traces of activity	646400	
3.1.3.56	H219A	site-directed mutagenesis, mutation in the P-loop/alpha-helix4, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview	751120	
3.1.3.56	H385A	no activity	646400	
3.1.3.56	H730A	no activity	646400	
3.1.3.56	K184A	site-directed mutagenesis, mutation in the Flex-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview	-, 751120	
3.1.3.56	K218A	site-directed mutagenesis, mutation in the P-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview	751120	
3.1.3.56	K250A	site-directed mutagenesis, mutation in the alpha4-alpha5-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview	751120	
3.1.3.56	K386A	no activity	646400	
3.1.3.56	additional information	construction of transgenic Arabidopsis thaliana plants expressing the human enzyme, the transgenic plants show no altered growth and life cycle phenotype although the basal level of inositol 1,4,5-trisphosphate is reduced by 90% compared to wild-type plants, but the plants are insensitive to gravitropic stimulation and show no increased InsP3 levels in inflorescence stem under gravistimulation in contrast to wild-type plants, bending responses, overview	666645