2.1.1.170	C172S/A14C	site-directed mutagenesis	-, 779252	
2.1.1.170	D56A	site-directed mutagenesis of the catalytic residue, the mutant is streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	D71A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-resistant and catalytically inactive	721042	
2.1.1.170	D96A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-resistant and catalytically inactive	721042	
2.1.1.170	G73A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-sensitive and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	G75A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	G75A	the mutation directly affects the S-adenosyl-L-methionine binding site, presents an almost 4fold loss of affinity and maintains the enzyme active	733472	
2.1.1.170	G77A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-resistant and catalytically inactive	721042	
2.1.1.170	H53A	site-directed mutagenesis of the catalytic residue, the mutant is partly streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	K100A/R101A	site-directed mutagenesis of the RNA-binding residues, the mutant is streptomycin-resistant and catalytically inactive	721042	
2.1.1.170	K165A	site-directed mutagenesis of the RNA binding residue, the mutant is streptomycin-sensitive, but shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	additional information	a rsmG null mutant is streptomycin-resistant	721042	
2.1.1.170	additional information	mutations within the gene gidB confer low-level streptomycin resistance. gidB mutations emerge spontaneously at a high frequency of 0.000001 and, once emerged, result in vigorous emergence of high-level streptomycin-resistant mutants at a frequency more than 2000 times greater than that seen in wild-type strains	-, 705767	
2.1.1.170	N39A	inactive	733472	
2.1.1.170	P79A	site-directed mutagenesis of the S-adenosyl-L-methionine-binding residue, the mutant is streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	R123A	site-directed mutagenesis of the RNA-binding residue, the mutant is streptomycin-sensitive, but shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	R139A	site-directed mutagenesis of the catalytic residue, the mutant is streptomycin-resistant and catalytically inactive	721042	
2.1.1.170	R139K	site-directed mutagenesis of the catalytic residue, the mutant is partly streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042	
2.1.1.170	R197A	site-directed mutagenesis of the RNA binding residue, the mutant is streptomycin-resistant and shows reduced activity compared to the wild-type enzyme	721042