6.3.4.21	Bone Marrow Failure Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098966&form=6&db=m	The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants.	unassigned	-	
6.3.4.21	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204194&form=6&db=m	Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,3,0	
6.3.4.21	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204194&form=6&db=m	Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,3,0	
6.3.4.21	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703994&form=6&db=m	The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,1,4	
6.3.4.21	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22570471&form=6&db=m	Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner.	causal interaction,therapeutic application,unassigned	3,1,0	
6.3.4.21	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197538&form=6&db=m	NAD+ depletion radiosensitizes 2-DG-treated glioma cells by abolishing metabolic adaptation.	causal interaction,therapeutic application,unassigned	2,1,0	
6.3.4.21	Glucose Intolerance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27592202&form=6&db=m	Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.	causal interaction,unassigned	3,0	
6.3.4.21	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21492230&form=6&db=m	Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
6.3.4.21	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703994&form=6&db=m	The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,1,4	
6.3.4.21	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515945&form=6&db=m	A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor.	causal interaction,therapeutic application,unassigned	4,4,0