6.2.1.64	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694406&form=6&db=m	ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.	causal interaction,therapeutic application,unassigned	3,4,0	
6.2.1.64	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14557245&form=6&db=m	APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.	causal interaction,unassigned	4,0	
6.2.1.64	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20827337&form=6&db=m	Amyloid Precursor Protein Binding Protein-1 Is Up-regulated in Brains of Tg2576 Mice.	causal interaction,ongoing research,unassigned	4,4,0	
6.2.1.64	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32579500&form=6&db=m	Melatonin Prevents Neddylation Dysfunction in A?42-Exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor Protein- Binding Protein 1 Pathway.	causal interaction,unassigned	1,0	
6.2.1.64	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22457814&form=6&db=m	The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.	ongoing research,therapeutic application,unassigned	3,4,0	
6.2.1.64	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30198810&form=6&db=m	AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor.	therapeutic application,unassigned	4,0	
6.2.1.64	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32360865&form=6&db=m	Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1.	ongoing research,therapeutic application,unassigned	2,1,0	
6.2.1.64	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213570&form=6&db=m	Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.	causal interaction,therapeutic application,unassigned	3,2,0	
6.2.1.64	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28468780&form=6&db=m	Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,3,0	
6.2.1.64	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33547247&form=6&db=m	Correction: Combined Inhibition of NEDD8-activating Enzyme and mTOR Suppresses NF2 Loss-driven Tumorigenesis.	causal interaction,therapeutic application,unassigned	2,2,0