3.4.22.69	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32924827&form=6&db=m	Potential protease inhibitors and their combinations to block SARS-CoV-2.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.69	Atherosclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143327&form=6&db=m	[Protease inhibitors and ectasia in coronary atherosclerosis]	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,4,0	
3.4.22.69	Atherosclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016275&form=6&db=m	The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting NADPH oxidizing enzyme expression.	causal interaction,unassigned	4,0	
3.4.22.69	Bronchitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17183167&form=6&db=m	Preliminary crystallographic analysis of avian infectious bronchitis virus main protease.	unassigned	-	
3.4.22.69	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31694340&form=6&db=m	ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.22.69	Communicable Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33415017&form=6&db=m	Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.	causal interaction,therapeutic application,unassigned	4,3,0	
3.4.22.69	Coronary Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143327&form=6&db=m	[Protease inhibitors and ectasia in coronary atherosclerosis]	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,4,0	
3.4.22.69	Coronavirus Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216498&form=6&db=m	Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor.	causal interaction,therapeutic application,unassigned	2,4,0	
3.4.22.69	Coronavirus Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16250642&form=6&db=m	A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods.	causal interaction,therapeutic application,unassigned	2,4,0	
3.4.22.69	Coronavirus Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25945576&form=6&db=m	Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity.	unassigned	-