3.4.22.61	Acantholysis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014554&form=6&db=m	The interaction of pemphigus autoimmunoglobulins with epidermal cells: activation of the fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients.	unassigned	-	
3.4.22.61	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11000244&form=6&db=m	Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.61	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861282&form=6&db=m	Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,1,0	
3.4.22.61	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30876938&form=6&db=m	TLR3 is involved in paraquat-induced acute renal injury.	causal interaction,unassigned	3,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10568827&form=6&db=m	Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFN-gamma through caspase 3 and caspase 8.	therapeutic application,unassigned	2,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11497260&form=6&db=m	Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.	ongoing research,unassigned	1,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067831&form=6&db=m	In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,4,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636156&form=6&db=m	Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.	diagnostic usage,ongoing research,unassigned	3,3,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025952&form=6&db=m	[Expression of cellular FLICE inhibitory protein (cFLIP) in endometrial adenocarcinoma]	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.61	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087380&form=6&db=m	Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression.	causal interaction,therapeutic application,unassigned	4,1,0