2.5.1.16	Brain Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3928144&form=6&db=m	Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.5.1.16	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26277788&form=6&db=m	Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,4,1,0	
2.5.1.16	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7332714&form=6&db=m	Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase.	ongoing research,therapeutic application,unassigned	2,1,0	
2.5.1.16	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4005290&form=6&db=m	Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,4,1,0	
2.5.1.16	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7608122&form=6&db=m	Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.	ongoing research,unassigned	4,0	
2.5.1.16	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9020892&form=6&db=m	Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.5.1.16	Chagas Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12653650&form=6&db=m	Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.	unassigned	-	
2.5.1.16	Chagas Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881725&form=6&db=m	An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi.	causal interaction,unassigned	2,0	
2.5.1.16	Chagas Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751689&form=6&db=m	In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.	therapeutic application,unassigned	4,0	
2.5.1.16	Cysts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965964&form=6&db=m	Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii.	therapeutic application,unassigned	1,0