2.7.11.10 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24917786&form=6&db=m In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19546526&form=6&db=m Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12831615&form=6&db=m [Potential molecular mechanism of multiple organ dysfunction syndrome induced by hemorrhage and endotoxin] causal interaction,unassigned 4,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515677&form=6&db=m Cytokine-activated degradation of inhibitory kappaB protein alpha is inhibited by the short-chain fatty acid butyrate. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12725325&form=6&db=m Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353139&form=6&db=m GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30105668&form=6&db=m Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.10 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243472&form=6&db=m Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17132819&form=6&db=m Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0