2.4.1.223	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11382776&form=6&db=m	A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAcalpha 1-->Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin.	ongoing research,unassigned	1,0	
2.4.1.223	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347583&form=6&db=m	Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.	causal interaction,ongoing research,unassigned	4,1,0	
2.4.1.223	Demyelinating Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703234&form=6&db=m	The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.	unassigned	-	
2.4.1.223	Exostoses, Multiple Hereditary	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121397&form=6&db=m	rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	causal interaction,unassigned	1,0	
2.4.1.223	Exostoses, Multiple Hereditary	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237233&form=6&db=m	Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.	causal interaction,ongoing research,unassigned	1,1,0	
2.4.1.223	glucuronosyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347583&form=6&db=m	Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.	causal interaction,ongoing research,unassigned	4,1,0	
2.4.1.223	Kashin-Beck Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517548&form=6&db=m	Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.	causal interaction,diagnostic usage,unassigned	2,1,0	
2.4.1.223	Mucopolysaccharidoses	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690583&form=6&db=m	Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.	therapeutic application,unassigned	4,0	
2.4.1.223	Mucopolysaccharidosis III	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690583&form=6&db=m	Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.	therapeutic application,unassigned	4,0	
2.4.1.223	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10318803&form=6&db=m	The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.	causal interaction,unassigned	1,0