2.3.1.B41	Acne Vulgaris	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30105859&form=6&db=m	Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP.	causal interaction,therapeutic application,unassigned	4,4,0	
2.3.1.B41	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373150&form=6&db=m	Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.	causal interaction,unassigned	4,0	
2.3.1.B41	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700227&form=6&db=m	Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy.	causal interaction,ongoing research,unassigned	2,3,0	
2.3.1.B41	Acute Lung Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784091&form=6&db=m	Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2.	ongoing research,unassigned	2,0	
2.3.1.B41	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27180906&form=6&db=m	SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,1,3	
2.3.1.B41	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283646&form=6&db=m	Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6.	causal interaction,therapeutic application,unassigned	4,4,0	
2.3.1.B41	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32787077&form=6&db=m	Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.	causal interaction,therapeutic application,unassigned	3,4,0	
2.3.1.B41	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180037&form=6&db=m	SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.3.1.B41	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31399301&form=6&db=m	SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,3,1,0	
2.3.1.B41	Adenoviridae Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670969&form=6&db=m	SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.	causal interaction,therapeutic application,unassigned	3,4,0