2.3.1.286	Acidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085245&form=6&db=m	The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.	therapeutic application,unassigned	4,0	
2.3.1.286	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443029&form=6&db=m	New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.	causal interaction,diagnostic usage,unassigned	2,2,0	
2.3.1.286	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943955&form=6&db=m	p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
2.3.1.286	Acute Coronary Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342474&form=6&db=m	Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,1	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20139070&form=6&db=m	Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.	causal interaction,ongoing research,therapeutic application,unassigned	2,4,2,0	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416250&form=6&db=m	Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.	causal interaction,ongoing research,therapeutic application,unassigned	2,1,1,0	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23302720&form=6&db=m	The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.	causal interaction,ongoing research,therapeutic application,unassigned	2,3,2,0	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896770&form=6&db=m	Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,2,0	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386563&form=6&db=m	Renal protective effect of sirtuin 1.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.3.1.286	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607838&form=6&db=m	Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.	unassigned	-