6.2.1.4 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392745&form=6&db=m Disorders caused by deficiency of succinate-CoA ligase. causal interaction,unassigned 4,0 6.2.1.4 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227526&form=6&db=m Marked mitochondrial DNA depletion associated with a novel SUCLG1 gene mutation resulting in lethal neonatal acidosis, multi-organ failure, and interrupted aortic arch. causal interaction,unassigned 4,0 6.2.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526370&form=6&db=m A novel missense mutation in SUCLG1 associated with mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria. causal interaction,unassigned 3,0 6.2.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21093335&form=6&db=m Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder. causal interaction,ongoing research,unassigned 4,2,0 6.2.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21639866&form=6&db=m Neonatal lactic acidosis with methylmalonic aciduria by novel mutations in the SUCLG1 gene. causal interaction,unassigned 4,0 6.2.1.4 Adenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174878&form=6&db=m Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients. unassigned - 6.2.1.4 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28709933&form=6&db=m Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. diagnostic usage,therapeutic application,unassigned 3,1,0 6.2.1.4 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174878&form=6&db=m Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients. unassigned - 6.2.1.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25027320&form=6&db=m SUCLG2 identified as both a determinator of CSF A?1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. causal interaction,unassigned 2,0 6.2.1.4 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727444&form=6&db=m Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia. causal interaction,unassigned 2,0 6.2.1.4 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740690&form=6&db=m X-linked Sideroblastic Anemia Due to Carboxyl-terminal ALAS2 Mutations That Cause Loss of Binding to the ?-Subunit of Succinyl-CoA Synthetase (SUCLA2). causal interaction,unassigned 4,0 6.2.1.4 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28709933&form=6&db=m Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. diagnostic usage,therapeutic application,unassigned 3,1,0 6.2.1.4 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Cardiomyopathy, Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26475597&form=6&db=m Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 6.2.1.4 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053772&form=6&db=m Effect of Citric Acid Cycle Genetic Variants and Their Interactions with Obesity, Physical Activity and Energy Intake on the Risk of Colorectal Cancer: Results from a Nested Case-Control Study in the UK Biobank. causal interaction,unassigned 1,0 6.2.1.4 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2936621&form=6&db=m Inhibition by streptozotocin of the activity of succinyl-CoA synthetase in vitro and in vivo. causal interaction,ongoing research,unassigned 1,1,0 6.2.1.4 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28749033&form=6&db=m Co-occurring Down syndrome and SUCLA2-related mitochondrial depletion syndrome. causal interaction,unassigned 4,0 6.2.1.4 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284138&form=6&db=m Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, papio anubis. causal interaction,ongoing research,unassigned 1,2,0 6.2.1.4 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26475597&form=6&db=m Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 6.2.1.4 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28035070&form=6&db=m Elucidation of the genetic and epigenetic landscape alterations in RNA binding proteins in glioblastoma. ongoing research,unassigned 1,0 6.2.1.4 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31836543&form=6&db=m Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. causal interaction,unassigned 1,0 6.2.1.4 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197121&form=6&db=m New SUCLG1 patients expanding the phenotypic spectrum of this rare cause of mild methylmalonic aciduria. causal interaction,therapeutic application,unassigned 3,1,0 6.2.1.4 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26758110&form=6&db=m [Diagnosis of mitochondrial disorders in children with next generation sequencing]. causal interaction,unassigned 3,0 6.2.1.4 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27896121&form=6&db=m A SUCLG1 mutation in a patient with mitochondrial DNA depletion and congenital anomalies. causal interaction,therapeutic application,unassigned 4,1,0 6.2.1.4 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Mitochondrial Encephalomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27484306&form=6&db=m Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. causal interaction,unassigned 4,0 6.2.1.4 Mitochondrial Encephalomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29217198&form=6&db=m Clinical, Molecular, and Computational Analysis in two cases with mitochondrial encephalomyopathy associated with SUCLG1 mutation in a consanguineous family. causal interaction,diagnostic usage,unassigned 4,4,0 6.2.1.4 Mitochondrial Encephalomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230783&form=6&db=m SUCLG1 mutations and mitochondrial encephalomyopathy: a case study and review of the literature. causal interaction,therapeutic application,unassigned 3,1,0 6.2.1.4 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23385875&form=6&db=m Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options. causal interaction,unassigned 1,0 6.2.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29850612&form=6&db=m Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia. unassigned - 6.2.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32963351&form=6&db=m EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 6.2.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415331&form=6&db=m Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 6.2.1.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23050596&form=6&db=m Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis. unassigned - 6.2.1.4 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415331&form=6&db=m Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 6.2.1.4 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415349&form=6&db=m Another Weak Link in the Electron Transport Chain: Variants in SUCLG2 and Risk for Pheochromocytoma and Paraganglioma. diagnostic usage,therapeutic application,unassigned 2,1,0 6.2.1.4 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415331&form=6&db=m Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 6.2.1.4 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415349&form=6&db=m Another Weak Link in the Electron Transport Chain: Variants in SUCLG2 and Risk for Pheochromocytoma and Paraganglioma. diagnostic usage,therapeutic application,unassigned 2,1,0 6.2.1.4 Porphyrias, Hepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3350152&form=6&db=m Physiological roles of animal succinate thiokinases. Specific association of the guanine nucleotide-linked enzyme with haem biosynthesis. causal interaction,unassigned 4,0 6.2.1.4 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32963351&form=6&db=m EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 6.2.1.4 pyruvate dehydrogenase system deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22231385&form=6&db=m Neonatal onset of mitochondrial disorders in 129 patients: clinical and laboratory characteristics and a new approach to diagnosis. causal interaction,unassigned 4,0 6.2.1.4 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484326&form=6&db=m Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. causal interaction,unassigned 4,0 6.2.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017724&form=6&db=m Deficiency of succinyl-CoA synthetase ? subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila. causal interaction,unassigned 3,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301081&form=6&db=m SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness. causal interaction,diagnostic usage,unassigned 4,2,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20693550&form=6&db=m The severity of phenotype linked to SUCLG1 mutations could be correlated with residual amount of SUCLG1 protein. causal interaction,unassigned 4,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26028457&form=6&db=m Five novel SUCLG1 mutations in three Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria. causal interaction,unassigned 4,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26475597&form=6&db=m Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26952923&form=6&db=m Novel mutation in SUCLA2 identified on sequencing analysis. causal interaction,therapeutic application,unassigned 4,1,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27143079&form=6&db=m [Clinical and laboratory studies on four Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria]. causal interaction,diagnostic usage,unassigned 4,2,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27484306&form=6&db=m Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. causal interaction,unassigned 4,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27496549&form=6&db=m Two transgenic mouse models for beta subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. causal interaction,unassigned 3,0 6.2.1.4 succinate-coa ligase (gdp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31240156&form=6&db=m Phenotypic variability in deficiency of the ? subunit of succinate-CoA ligase. causal interaction,unassigned 4,0 6.2.1.4 Vitamin B 12 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29808036&form=6&db=m Diagnostic dilemma of patients with methylmalonic aciduria: Experience from a tertiary care centre in Pakistan. unassigned -