3.5.3.18 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31763675&form=6&db=m DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase. therapeutic application,unassigned 1,0 3.5.3.18 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24134589&form=6&db=m Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.18 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515557&form=6&db=m Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.18 Adenocarcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515557&form=6&db=m Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.18 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515557&form=6&db=m Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.18 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23635662&form=6&db=m Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy. ongoing research,unassigned 4,0 3.5.3.18 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9840734&form=6&db=m Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.5.3.18 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31755389&form=6&db=m Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease. causal interaction,unassigned 1,0 3.5.3.18 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25194333&form=6&db=m Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26226438&form=6&db=m FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis. ongoing research,unassigned 4,0 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34438260&form=6&db=m Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.18 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29070803&form=6&db=m MiR-193b regulates breast cancer cell migration and vasculogenic mimicry by targeting dimethylarginine dimethylaminohydrolase 1. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.18 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442289&form=6&db=m Circ_0004771 Accelerates Cell Carcinogenic Phenotypes via Suppressing miR-1253-Mediated DDAH1 Inhibition in Breast Cancer. unassigned - 3.5.3.18 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663142&form=6&db=m A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.18 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151866&form=6&db=m DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.18 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442289&form=6&db=m Circ_0004771 Accelerates Cell Carcinogenic Phenotypes via Suppressing miR-1253-Mediated DDAH1 Inhibition in Breast Cancer. unassigned - 3.5.3.18 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155659&form=6&db=m DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma. diagnostic usage,unassigned 1,0 3.5.3.18 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28741166&form=6&db=m A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1. causal interaction,unassigned 3,0 3.5.3.18 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819685&form=6&db=m Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.18 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762558&form=6&db=m Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.5.3.18 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34533401&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II - induced cardiac hypertrophy and vascular remodeling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.5.3.18 Cardiovascular Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959216&form=6&db=m Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction. causal interaction,unassigned 3,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834755&form=6&db=m Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats. therapeutic application,unassigned 1,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27187323&form=6&db=m Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development. unassigned - 3.5.3.18 Carotid Artery Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019334&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.18 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250061&form=6&db=m Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24470527&form=6&db=m Asymmetric dimethylarginine and DDAH1 transcript variants in cardiovascular and cerebrovascular diseases. unassigned - 3.5.3.18 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33433489&form=6&db=m DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study. causal interaction,unassigned 3,0 3.5.3.18 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013773&form=6&db=m Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis. causal interaction,ongoing research,unassigned 2,4,0 3.5.3.18 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144995&form=6&db=m Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24934151&form=6&db=m Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients. ongoing research,unassigned 4,0 3.5.3.18 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677852&form=6&db=m Dimethylarginine Dimethylaminohydrolase 2 (DDAH 2) Gene Polymorphism, Asymmetric Dimethylarginine (ADMA) Concentrations, and Risk of Coronary Artery Disease: A Case-Control Study. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.18 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20167924&form=6&db=m A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.18 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923027&form=6&db=m Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.5.3.18 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359292&form=6&db=m ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.18 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278301&form=6&db=m Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270117&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12186805&form=6&db=m Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. causal interaction,unassigned 4,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24186881&form=6&db=m Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359292&form=6&db=m ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303562&form=6&db=m The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study. causal interaction,ongoing research,unassigned 2,3,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22521321&form=6&db=m Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558392&form=6&db=m A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22579530&form=6&db=m Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702602&form=6&db=m The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24186881&form=6&db=m Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701782&form=6&db=m Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: Role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31733101&form=6&db=m DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner. causal interaction,unassigned 3,0 3.5.3.18 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30569164&form=6&db=m DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats. causal interaction,unassigned 2,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917889&form=6&db=m Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. causal interaction,unassigned 3,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260221&form=6&db=m DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26806551&form=6&db=m DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. causal interaction,unassigned 4,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181226&form=6&db=m Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594240&form=6&db=m Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.18 dimethylargininase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402164&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270117&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.18 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270117&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.18 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29119338&form=6&db=m Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22395885&form=6&db=m Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.18 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237779&form=6&db=m Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.18 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941821&form=6&db=m Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.18 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256062&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.18 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31669648&form=6&db=m Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity. unassigned - 3.5.3.18 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23878601&form=6&db=m Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310909&form=6&db=m Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. causal interaction,unassigned 3,0 3.5.3.18 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26923818&form=6&db=m Effect of asymmetric dimethylarginine (ADMA) on heart failure development. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.18 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31274368&form=6&db=m Correlation of gene expression and clinical parameters identifies a set of genes reflecting LV systolic dysfunction and morphological alterations. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.18 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402164&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474717&form=6&db=m The Involvement of DDAH1 in the Activation of Spinal NOS Signaling in Early Stage of Mechanical Allodynia Induced by Exposure to Ischemic Stress in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.5.3.18 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293168&form=6&db=m Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22075968&form=6&db=m Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17895252&form=6&db=m Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18567702&form=6&db=m Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. ongoing research,unassigned 3,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019334&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25792109&form=6&db=m Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26708340&form=6&db=m Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.18 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27545130&form=6&db=m [Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia]. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911182&form=6&db=m Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2. causal interaction,unassigned 1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16444868&form=6&db=m DDAH gene and cardiovascular risk. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408977&form=6&db=m Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. unassigned - 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24303100&form=6&db=m Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF. causal interaction,unassigned 4,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25294342&form=6&db=m Involvement of inducible nitric oxide synthase and dimethyl arginine dimethylaminohydrolase in N?-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. unassigned - 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375520&form=6&db=m Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats. causal interaction,unassigned 4,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26826640&form=6&db=m Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol? causal interaction,unassigned 3,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31755934&form=6&db=m Angiotensin II inhibits DDAH1-nNOS signaling via AT1R and ?OR dimerization to modulate blood pressure control in the central nervous system. causal interaction,unassigned 3,0 3.5.3.18 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23302093&form=6&db=m Basal release of NO in the mesenteric artery in portal hypertension and cirrhosis: role of dimethylarginine dimethylaminohydrolase. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.18 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152204&form=6&db=m Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension. therapeutic application,unassigned 1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615801&form=6&db=m Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. ongoing research,unassigned 1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827267&form=6&db=m Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20840872&form=6&db=m Involvement of asymmetric dimethylarginine and Rho kinase in the vascular remodeling in monocrotaline-induced pulmonary hypertension. causal interaction,unassigned 3,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641341&form=6&db=m Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402164&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281630&form=6&db=m Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice. diagnostic usage,ongoing research,unassigned 2,4,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151866&form=6&db=m DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.18 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641341&form=6&db=m Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.18 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281630&form=6&db=m Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice. diagnostic usage,ongoing research,unassigned 2,4,0 3.5.3.18 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26407009&form=6&db=m Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239148&form=6&db=m Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558392&form=6&db=m A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23593273&form=6&db=m FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702602&form=6&db=m The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359292&form=6&db=m ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29391561&form=6&db=m Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle. therapeutic application,unassigned 2,0 3.5.3.18 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002792&form=6&db=m Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.18 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135237&form=6&db=m Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression. unassigned - 3.5.3.18 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21136910&form=6&db=m The glomerular proteome in a model of chronic kidney disease. causal interaction,unassigned 1,0 3.5.3.18 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21528130&form=6&db=m Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.18 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30308196&form=6&db=m Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy. ongoing research,unassigned 2,0 3.5.3.18 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25523831&form=6&db=m The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine. ongoing research,unassigned 4,0 3.5.3.18 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33360846&form=6&db=m Downregulating miR-96-5p promotes proliferation, migration, and invasion, and inhibits apoptosis in human trophoblast cells via targeting DDAH1. diagnostic usage,unassigned 3,0 3.5.3.18 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26407009&form=6&db=m Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.5.3.18 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24574257&form=6&db=m Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 3.5.3.18 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34283907&form=6&db=m Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population. therapeutic application,unassigned 2,0 3.5.3.18 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662939&form=6&db=m Genotype/allelic combinations as potential predictors of myocardial infarction. diagnostic usage,unassigned 1,0 3.5.3.18 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28145161&form=6&db=m Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression. causal interaction,unassigned 4,0 3.5.3.18 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28580735&form=6&db=m DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605276&form=6&db=m Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia. unassigned - 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14750034&form=6&db=m Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. ongoing research,unassigned 2,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384941&form=6&db=m Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. unassigned - 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979083&form=6&db=m Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. therapeutic application,unassigned 2,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26082478&form=6&db=m Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL. therapeutic application,unassigned 1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150732&form=6&db=m Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently upregulated in prostate cancer, and its overexpression conveys tumor growth and angiogenesis by metabolizing asymmetric dimethylarginine (ADMA). ongoing research,unassigned 1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872669&form=6&db=m Esophageal Squamous Cell Carcinoma Is Accompanied by Local and Systemic Changes in L-arginine/NO Pathway. ongoing research,unassigned 1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442289&form=6&db=m Circ_0004771 Accelerates Cell Carcinogenic Phenotypes via Suppressing miR-1253-Mediated DDAH1 Inhibition in Breast Cancer. unassigned - 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439753&form=6&db=m Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers. ongoing research,unassigned 1,0 3.5.3.18 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31755389&form=6&db=m Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease. causal interaction,unassigned 1,0 3.5.3.18 nitric-oxide synthase (nadph) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666122&form=6&db=m ADMA and the role of the genes: Lessons from genetically modified animals and human gene polymorphisms. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.5.3.18 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308253&form=6&db=m Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data. causal interaction,unassigned 3,0 3.5.3.18 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105289&form=6&db=m OS075. Endothelial-dependent vascular function is significantly impaired in obesity and restored by overexpression of DDAH1: Evidence for the role of ADMA. causal interaction,unassigned 4,0 3.5.3.18 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25221746&form=6&db=m Dimethylarginine dimethylaminohydrolase (DDAH) overexpression attenuates agricultural organic dust extract-induced inflammation. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501905&form=6&db=m Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508323&form=6&db=m No Compensatory Upregulation of Placental Dimethylarginine Dimethylaminohydrolase Activity in Preeclampsia. causal interaction,unassigned 2,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18251679&form=6&db=m No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations. unassigned - 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19570459&form=6&db=m [Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22285683&form=6&db=m Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia. causal interaction,unassigned 1,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23012314&form=6&db=m Nitric Oxide and Carbon Monoxide Production and Metabolism in Preeclampsia. causal interaction,unassigned 2,0 3.5.3.18 Pregnancy Complications, Infectious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31821207&form=6&db=m Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.18 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23635662&form=6&db=m Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy. ongoing research,unassigned 4,0 3.5.3.18 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23097221&form=6&db=m The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.18 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409314&form=6&db=m Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.18 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20010544&form=6&db=m Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.18 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24125425&form=6&db=m A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease. causal interaction,unassigned 4,0 3.5.3.18 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594240&form=6&db=m Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.18 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214214&form=6&db=m Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.5.3.18 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979083&form=6&db=m Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. therapeutic application,unassigned 2,0 3.5.3.18 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22428028&form=6&db=m Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.5.3.18 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24611830&form=6&db=m Pharmacological inhibition of DDAH1 improves survival, hemodynamics and organ function in experimental septic shock. ongoing research,therapeutic application,unassigned 1,4,0 3.5.3.18 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30538005&form=6&db=m Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity. causal interaction,unassigned 1,0 3.5.3.18 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31821207&form=6&db=m Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.18 Sleep Wake Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30048696&form=6&db=m SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived rats. causal interaction,unassigned 3,0 3.5.3.18 Sleep Wake Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30861604&form=6&db=m Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.18 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164036&form=6&db=m Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH. causal interaction,unassigned 3,0 3.5.3.18 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155659&form=6&db=m DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma. diagnostic usage,unassigned 1,0 3.5.3.18 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28580735&form=6&db=m DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.18 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14638548&form=6&db=m Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. therapeutic application,unassigned 2,0 3.5.3.18 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250061&form=6&db=m Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20167924&form=6&db=m A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.18 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33574439&form=6&db=m DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. unassigned - 3.5.3.18 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068544&form=6&db=m Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.18 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019334&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.18 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20167924&form=6&db=m A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.18 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337775&form=6&db=m Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans. causal interaction,unassigned 1,0 3.5.3.18 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794631&form=6&db=m Renal asymmetric dimethylarginine inhibits fibrosis. ongoing research,unassigned 3,0 3.5.3.18 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850055&form=6&db=m DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission. unassigned - 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19603041&form=6&db=m Dimethylarginine dimethylaminohydrolase in rat penile tissue: reduced enzyme activity is responsible for erectile dysfunction in a rat model of atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20462645&form=6&db=m Improvement of endothelial dysfunction in atherosclerotic rabbit aortas by ex vivo gene transferring of dimethylarginine dimethylaminohydrolase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24690995&form=6&db=m Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.18 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33271854&form=6&db=m Sequence Variation in the DDAH1 Gene Predisposes for Delayed Cerebral Ischemia in Subarachnoidal Hemorrhage. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.18 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611984&form=6&db=m Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24186881&form=6&db=m Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29096857&form=6&db=m ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy. ongoing research,unassigned 1,0 3.5.3.18 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31818438&form=6&db=m ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.18 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31904280&form=6&db=m Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18156199&form=6&db=m Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772860&form=6&db=m Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118322&form=6&db=m Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402164&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879046&form=6&db=m Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method. therapeutic application,unassigned 1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895913&form=6&db=m miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.5.3.18 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025746&form=6&db=m Role of asymmetrical dimethylarginine in renal microvascular endothelial dysfunction in chronic renal failure with hypertension. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.18 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15543672&form=6&db=m Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237779&form=6&db=m Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332430&form=6&db=m Proteomic analysis of prostate cancer metastasis-derived prostasomes. causal interaction,unassigned 1,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590769&form=6&db=m Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32932854&form=6&db=m L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628783&form=6&db=m Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis. causal interaction,unassigned 1,0 3.5.3.18 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22428028&form=6&db=m Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.5.3.18 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25857313&form=6&db=m Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.18 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30538005&form=6&db=m Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity. causal interaction,unassigned 1,0 3.5.3.18 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20555425&form=6&db=m The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.18 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611984&form=6&db=m Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.5.3.18 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879046&form=6&db=m Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method. therapeutic application,unassigned 1,0 3.5.3.18 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920447&form=6&db=m Elevated dimethylarginine dimethylaminohydrolase (DDAH) activity in rheumatoid arthritis and spondyloarthritis. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16444868&form=6&db=m DDAH gene and cardiovascular risk. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677405&form=6&db=m Association of DDAH2 gene polymorphism with cardiovascular disease in Egyptian patients. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260221&form=6&db=m DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359292&form=6&db=m ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214214&form=6&db=m Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.5.3.18 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30284143&form=6&db=m AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians. causal interaction,diagnostic usage,unassigned 3,2,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702602&form=6&db=m The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.5.3.18 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19603041&form=6&db=m Dimethylarginine dimethylaminohydrolase in rat penile tissue: reduced enzyme activity is responsible for erectile dysfunction in a rat model of atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.18 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31394201&form=6&db=m DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls. causal interaction,diagnostic usage,unassigned 3,2,0 3.5.3.18 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21590769&form=6&db=m Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805079&form=6&db=m Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. causal interaction,unassigned 2,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23110194&form=6&db=m Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895913&form=6&db=m miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359292&form=6&db=m ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33214214&form=6&db=m Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.5.3.18 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25236572&form=6&db=m Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.5.3.18 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29892894&form=6&db=m Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29119338&form=6&db=m Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611984&form=6&db=m Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.5.3.18 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25236572&form=6&db=m Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.5.3.18 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535073&form=6&db=m Treatment of atherosclerosis through transplantation of endothelial progenitor cells overexpressing dimethylarginine dimethylaminohydrolase (DDAH) in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.18 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33433489&form=6&db=m DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study. causal interaction,unassigned 3,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982060&form=6&db=m Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells. causal interaction,unassigned 3,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701782&form=6&db=m Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: Role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.18 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23147199&form=6&db=m ADMA, SDMA and L-arginine/ADMA Ratio but not DDAH Genetic Polymorphisms are Reliable Predictors of Diabetic Nephropathy Progression as Identified by Competing Risk Analysis. diagnostic usage,unassigned 3,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21076854&form=6&db=m Mesenteric vascular remodeling in hyperhomocysteinemia. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26786611&form=6&db=m Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27251093&form=6&db=m N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. diagnostic usage,unassigned 3,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34533401&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II - induced cardiac hypertrophy and vascular remodeling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.5.3.18 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27565538&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 protects against high fat diet induced hepatic steatosis and insulin resistance in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,3 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941821&form=6&db=m Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604680&form=6&db=m Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256062&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569408&form=6&db=m Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28580735&form=6&db=m DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/?-catenin signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28741166&form=6&db=m A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1. causal interaction,unassigned 3,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30673277&form=6&db=m Novel Cellularly Active Inhibitor Regresses DDAH1 Induced Prostate Tumor Growth by Restraining Tumor Angiogenesis through Targeting DDAH1/ADMA/NOS Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31993367&form=6&db=m Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.18 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27565538&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 protects against high fat diet induced hepatic steatosis and insulin resistance in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,3 3.5.3.18 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349891&form=6&db=m Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.18 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465497&form=6&db=m Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293168&form=6&db=m Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20348244&form=6&db=m Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.18 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535073&form=6&db=m Treatment of atherosclerosis through transplantation of endothelial progenitor cells overexpressing dimethylarginine dimethylaminohydrolase (DDAH) in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550280&form=6&db=m Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. causal interaction,unassigned 4,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19331593&form=6&db=m Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23878601&form=6&db=m Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.18 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409409&form=6&db=m A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.18 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19775692&form=6&db=m Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.5.3.18 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209122&form=6&db=m Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.18 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052979&form=6&db=m Asymmetric dimethylarginine in hematological malignancies: a preliminary study. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666123&form=6&db=m Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.18 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22579530&form=6&db=m Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952847&form=6&db=m Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663142&form=6&db=m A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.18 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677199&form=6&db=m The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.18 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809508&form=6&db=m Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke. causal interaction,ongoing research,unassigned 2,4,0 3.5.3.18 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409409&form=6&db=m A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10377069&form=6&db=m Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22492959&form=6&db=m Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260221&form=6&db=m DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515557&form=6&db=m Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.18 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28145161&form=6&db=m Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression. causal interaction,unassigned 4,0 3.5.3.18 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30594923&form=6&db=m Altered methylation and expression patterns of genes regulating placental nitric oxide pathway in patients with severe preeclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.18 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24303100&form=6&db=m Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF. causal interaction,unassigned 4,0 3.5.3.18 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895913&form=6&db=m miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.5.3.18 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402164&form=6&db=m Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.18 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24611830&form=6&db=m Pharmacological inhibition of DDAH1 improves survival, hemodynamics and organ function in experimental septic shock. ongoing research,therapeutic application,unassigned 1,4,0 3.5.3.18 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31821207&form=6&db=m Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.18 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17601800&form=6&db=m Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0